As described hereinbefore, the cinnamaldehyde compound of Chemical Formula 1 or pharmaceutically acceptable salts thereof according to the present invention induce a G2/M cell cycle arrest in cancer cells, thereby inhibiting the abnormal growth of the cells, and also have improved solubility in water, thereby exhibiting higher anticancer effects.  PAL gives rise to trans-cinnamic acid. Then, 2 g of potassium carbonate and 0.8 g of 4-picolyl chloride were added to the solution and mixed with stirring for 5 hrs at room temperature. The cells were then fixed in 3 ml of 70% ethanol at −20° C. for 12 hrs. Like a clock, which is composed of three counters for seconds, minutes and hours, the cell cycle consists of four different phases: G1 (Gap1), S (DNA synthesis), G2 (Gap2) and M (mitosis) phases.
Moreover, cinnamaldehyde still has kept its antibacterial activity in cinnamaldehyde/CD-IC NF samples when tested against Escherichia coli. It is a yellowish oily, liquid with a sweet taste and a cinnamish odor responsible for the characteristic taste and odor of cinnamon spice. Occurring naturally as predominantly the trans isomer, it gives cinnamon its flavor and odor. As such, the molecule can be viewed as a derivative of acrolein. 1.2 g of the concentrate was dissolved in 30 ml of methylene chloride and subjected to column chromatography, which was performed using a silica gel (Merck, Art No. The test was conducted to determine the solubility range for which 0.1 gm of substance was dissolved in different solvents like acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The physicochemical properties of the compound of Chemical Formula 2 are given in Table 1, below, and the proton NMR spectrum of the compound is shown in FIG. CA has been demonstrated to exert antihyperglycemic and antihyperlipidemic actions in C57BLKS/J db/db mice.
All rights reserved. Sodium modified non-reduced Ru/SiO2 catalyst had hydrogenation properties very similar to reduced Ru/SiO2 catalyst. The present composition may be formulated for oral administration in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups or aerosols.
Although the preferred embodiments of the present invention have been disclosed for illustrative purposes, those skilled in the art will appreciate that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims. These events are a process that all cells undergo in order to grow and divide themselves into two cells, and are thus very important for maintaining the cell's life. Picolyl is particularly preferred. The HP-β-CD has shown slightly stronger binding with cinnamaldehyde when compared to HP-γ-CD for cinnamaldehyde/CD-IC. On the basis of this value, test chemical was considered to be soluble in water. 2009, 47, 61-66. Observe that for the parameters k3, k4, θ2 and θ3, the confidence interval is larger in absolute value than the corresponding parameter value. Also disclosed are a method of preparing the cinnamaldehyde compound and an anticancer composition including the compound of Chemical Formula 1. The D-type cyclins are associated with cyclin-dependant kinase (CDK) 2, 4 or 6 to regulate the activity of the enzyme, and protein phosphatases, such as CDC25, which dephosphorylate phosphorylated proteins, are very important regulators in the entire cell cycle. Al-Bayati, F. A.; Mohammed, M. J.
After the S phase is completed, cells enter the G2 phase, which is called the second checkpoint. When an abnormality occurs in any one of the signaling events, the events are balanced by their own regulatory mechanisms, but the abnormality often leads to disease. Wendakoon, C. N.; Sakaguchi, M. Inhibition of Amino Acid Decarboxylase Activity of Enterobacter aerogenes by Active Components in Spices. : 60 °C; H2O: 0.5 cm3, Time: 2 hr. Through antioxidant mechanism, the pancreatic β-cell protective effect in STZ-rats (e.g. This was most clearly observed in non-reduced catalysts. Solid formulations for oral administration may include tablets, pills, powders, granules and capsules, and are prepared by mixing the above compound with one or more excipients, such as starch, calcium carbonate, sucrose, lactose and gelatin. Welcome to the ECHA website. In one aspect, the present invention provides a cinnamaldehyde compound represented by Chemical Formula 1, below, or a pharmaceutically acceptable salt thereof. After 48 hrs, nuclear DNA was stained with propidium iodide. EC number: 203-213-9 | CAS number: 104-55-2. The daily dosage may be taken in a single dose, or may be divided into several doses. , Cinnamaldehyde was isolated from cinnamon essential oil in 1834 by Jean-Baptiste Dumas and Eugène-Melchior Péligot and synthesized in the laboratory by the Italian chemist Luigi Chiozza in 1854.  It is believed that the antimicrobial properties arise from the aldehyde group on Cinnamaldehyde. Please upgrade your Internet Explorer to a newer version. 1.
The parameter identification process was repeated for the 6 parameter model, where k4θ3 is replaced by k′4. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. Aberrant progression of the two checkpoints is associated with cellular aging or the development of diseases, such as cancer. After the reaction was completed, organic solvent phases containing an active substance were collected and concentrated under reduced pressure. An acid addition salt may be prepared using a common method, for example, by dissolving a compound in an excess amount of aqueous acid solution and precipitating the salt formed using a water-miscible organic solvent, such as methanol, ethanol, acetone or acetonitrile. Find more information about Crossref citation counts. You have to login with your ACS ID befor you can login with your Mendeley account. The highest activities were achieved with conventional ruthenium catalyst. Occurring naturally as predominantly the trans (E) isomer, it gives cinnamon its flavor and odor. All modes of administration are contemplated, for example, administration can be made orally, rectally or by intravenous, intramuscular, subcutaneous, intrathecal, epidural or intracerebroventricular injection. The essential oil of cinnamon bark is about 90% cinnamaldehyde. Effect of Hydrogen partial pressure on the conversion and selectivity. Tin modification and increased tin loading of reduced and modified catalysts increased the formation of the desired alcohol by decreasing the formation of saturated aldehyde.
Selectivity to COL as a function of conversior hydrogenation over 5%Ru-10%Sn/SiO2 and 5%Ru/SiO2.
Cinnamaldehyde is used in agriculture because of its low toxicity, but it is a skin irritant.
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
In biphasic mode of operation, scCO2-water (entry 4) and toluene-water (entry 3) systems were compared. Compared to vehicle control mice, no weight changes were observed in compound-received mice. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. One can thus speculate that, also in cinnamaldehyde hydrogenation, during the reaction there is in situ formation of sites responsible for the hydrogenation of the carbonyl group (formation of unsaturated alcohol). 1H-NMR (CDCl3): 9.69 (1H, d, J=7.2), 7.68 (1H, d, J=8.1), 7.51 (2H, m), 7.33 (1H, t, J=7.5), 7.22 (2H, d, J=8.1), 4.38 (2H, s), 3.56 (3H, s). J. Hajek, ... D. Yu.
Division, proliferation and differentiation of cells constituting the body are vital processes for the maintenance of life phenomena. Cinnamaldehyde (CA) has been reported to be the major component of volatile oils from cinnamon (Lauraceae).
The parameters k4 and θ3 exhibit extreme ill-conditioning as the confidence intervals are by four orders of magnitude larger than the parameter values. The additional step may further enhance the water solubility of the compound.